Mixing ibuprofen with common blood pressure medications can cause permanent kidney damage

WATERLOO, Ontario (StudyFinds.org) – If you’re currently taking a diuretic and a renin-angiotensin system (RSA) blocker for high blood pressure, University of Waterloo researchers warn that taking ibuprofen could be a combination very harmful. Scientists report that the combination of the three drugs can lead to acute kidney injury in certain medical profiles. In some cases, this kidney damage can be permanent.

Available under a wide variety of brand names, diuretics and RSA inhibitors are commonly prescribed together to help treat high blood pressure. Ibuprofen, on the other hand, is a widely available over-the-counter pain reliever.

The researchers used a series of computer-simulated drug trials to come to these conclusions. This strategy allowed them to model the interactions between the three drugs, as well as any impact on the kidneys.

“It’s not that everyone who takes this drug combination is going to have problems,” says Anita Layton, a professor of applied mathematics at Waterloo and holder of the Canada 150 Research Chair in Mathematical Biology and Medicine, in a university statement. . “But the research shows that’s enough of a problem that you should exercise caution.”

Dehydration plays a major role in kidney damage

Human clinical trials can take months or longer to produce results. Computer-simulated drug trials, however, are much faster. So Professor Layton and his team are using their math and computer expertise to create computer-simulated drug trials, giving medical practitioners a much earlier indication of any potential drug-drug interaction issues.

This time around, their findings directly apply to many, many people currently taking blood pressure medication. These people can take ibuprofen and have no idea that it is putting their kidneys at risk.

“Diuretics are a family of drugs that cause the body to retain less water,” Professor Layton concludes. “Dehydration is a major factor in acute kidney injury, and then the RAS inhibitor and ibuprofen hit the kidney with this triple whammy. consider acetaminophen instead.

The study is published in the journal Mathematical Biosciences.

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