Mixture of vaccines and modifications may have better effectiveness, experts say


Even though academic research is ongoing to find the efficacy of the two vaccines given against COVID-19, the inactivated virus vaccine mechanism is believed to be ideal for generating the required amount of immunity because of the period of effectiveness of both vaccines. is declared to be. about 9-12 months.

Senior virologist Dr Jacob John says the use of inactivated virus vaccines after two doses of vector virus vaccines will serve as a booster vaccine and improve the antibody response against COVID-19. “The response from a third dose of vector vaccine might not be as effective as an inactivated virus vaccine, because antibodies generated after the first two doses are likely to inactivate the virus early in their booster response. So those who take vector vaccines, inactivated virus vaccines will help build immunity, ”says Dr. Jacob John.

Meanwhile, researchers are studying the impact of the third dose of inactivated virus in healthy individuals after six months of full vaccination. Dr Sathyajit Mohapatra, principal investigator of the Covaxin trials at SRM Medical College and Research Center, said the effectiveness of booster doses of inactivated virus in the case of Covaxin is being studied to monitor adaptations to be made as that more variants are emerging because the immune response of Covaxin differs in the case of the Delta variant and the Delta Plus variant. “Adaptations in terms of other variants need to be explored and mixing of vaccines could be beneficial, as foreign studies suggest. However, mixing of vaccines also has its concerns and side effects in those with co-morbidities will be crucial. “, did he declare. mentionned.

With the continued shortage of vaccines and unavailability, mixing the vaccines for the third dose will only lead to precipitation and confusion, says public health expert Dr K Kolandaisamy. He added that as the nature of the virus changes over time and variants develop, there is a need to modify the vaccines for the third dose.


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