Singapore suggests that Pfizer beneficiaries get a Moderna booster. Should we do it too?

A nurse places two vials of the COVID-19 coronavirus vaccine (left to right): Pfizer-BioNTech and Moderna, on a table before administering doses at a Clalit Health Services medical center in East Jerusalem on the 10th. August 2021. (Photo by HAZEM BADER / AFP) (Photo by HAZEM BADER / AFP via Getty Images)

(NEXSTAR) – Singapore’s health minister advises people who have received two doses of Pfizer to consider mixing them this time around.

Those who received Pfizer for their first two doses, and then receive a booster from Moderna, are 72% less likely to be infected with COVID-19, Health Minister Ong Ye Kung said at a conference on Monday. hurry. Those who receive the Pfizer vaccine for all three doses are 62% less likely to be infected, Yahoo News reports.

“Both mRNA vaccines work very well as boosters, with Pfizer-Pfizer-Moderna having a slight advantage,” he said. “Either way, the impact on reducing disease severity is extremely high for both combinations.”

The health minister said they were also looking at the effectiveness of Moderna-Moderna-Pfizer, but the sample size studied so far was still too small to draw meaningful conclusions.

In the United States, mixing and pairing of vaccine doses is now permitted. It is especially recommended for those who received the Johnson & Johnson vaccine for their first round of vaccination.

When the new booster mix-and-match rules were announced last month, we asked Dr. Bob Wachter, director of the Department of Medicine at the University of California at San Francisco, what he would do if he was a J&J recipient: get another dose of J&J or some other guy?

“No question: I would get an mRNA,” Wachter said, giving Moderna a slight advantage over Pfizer when given the choice.

Wachter said there was less evidence to support the mixing and pairing of Pfizer and Moderna at the time. “There is weak evidence that using the other mRNA could lead to a slightly stronger response,” he said.

The only scenario in which Wachter strongly suggests mixing and pairing is if you had an adverse reaction to Pfizer or Moderna the first time, other than the routine side effects. In this case, you may want to talk to your doctor about the possibility of receiving the other type of vaccine for your booster.

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